For my third scan I opted for a different approach. I used VueScan and opted for a multiple pass scan (which in effect scans the slide 3 times to obtain the greatest amount data from the slide). I imported this scan into Lightroom and made my corrections for color, contrast (local and global), saturation and etc, but also used the noise suppression feature. Since this results in an over-all softening of the image, afterwards I locally sharpened key areas of the image.